spray dryer crystalline structure

The production of crystalline powders by spray drying to

The drying mechanism was then investigated through the co-spray drying of the API with LαH2O using the same spray dryer inlet temperatures and solvent compositions. PAR and LαH2O were co-SD at various Tin and Sc to investigate the effect of these parameters on the co-processing of the two components.

Amorphous and crystalline aerosol particles interacting

2020-7-31 · solid crystalline particles is often not spherical, and polycrys-talline materials and agglomerates may also be porous. The porosity of crystalline sub-micron aerosol particles generated by spray drying, however, is usually not very high (appar-ent void fractions <20%; Kramer et al., 2000; DeCarlo et¨ al., 2004; Mikhailov et al., 2004).

PLA/PLGA nanoparticles prepared by nano spray drying

2019-4-16 · Background Spray drying is a relatively simple, fast, reproducible and scalable drying technology that is suitable for drying heat-sensitive biopharmaceutical compounds. In view of the rapid progress of nanoencapsulation technologies in the pharmaceutical sector, nano spray drying is used in research to improve the powder formulation and release of active ingredients. The …

Spray drying formulation of amorphous solid dispersions - …

2016-5-1 · For the context of this review, spray dryer equipment can be viewed as solid state transforming reactors where the crystalline starting material is converted into amorphous product. The first patent of spray drying process is more than 140 years old wherein it was described as a process for simultaneously atomizing and desicing fluid and

Impact of Crystalline and Amorphous Matrices on …

2021-5-7 · During the spray drying process, minor changes of T‐Out were observed. Hence, T‐Out was reported as mean with a deviation of ± 1.5 °C. 2.6 Z‐Average and PDI Measurements. To compare the effects of pumping and spray drying on polyplex content, 70 µL of freshly prepared polyplex suspension was compared to polyplexes after further processing.

Rapidly expanding starches with altered crystalline structure

Preparation of a Labile Birefringent Starch by Spray Drying. One Step Process. Spray drying was performed on a Niro Spray Dryer with a two fluid nozzle. The starch as prepared in Example 1 was slurried at 20-30% (w/w) solids in water and was introduced directly into the nozzle with the feed pressure of 20.6-24.0 MPa.

(PDF) Spray drying: A crystallization technique : …

2022-4-11 · There are three fundamental [42, 45-46] steps (figure 1) involved in spray drying. 1) Atomization of a liquid feed into fine droplets. 2) M ixing of t hese spray droplets with a heated gas stream

SPRAY-DRIED DISPERSIONS - Particle …

Spray drying from solutions is a much more conventional approach for SDDs in oral solid dosage form development, whereas spray drying from emulsions is more common in industries such as food and cosmetics, where it has been …

(PDF) Spray drying: A crystallization technique : …

2022-4-11 · There are three fundamental [42, 45-46] steps (figure 1) involved in spray drying. 1) Atomization of a liquid feed into fine droplets. 2) M ixing of t …

Physical Characteristics of Amorphous and …

2020-9-14 · From Figure 3, it could be seen that the vacuum-dried coconut sugar with a predominant amorphous structure showed higher water sorption than the conventional one.Amorphous sugar adsorbs more water than its crystalline …

Formation and physicochemical properties of crystalline

2017-9-14 · amorphous salts of atorvastatin manufactured by spray drying, concluded that greater dissolution rates, in comparison to the crystalline counterparts, were obtained using amorphous salts of magnesium and calcium, but not sodium.17 Hasa et al. obtained a rapidly and highly absorbed amorphous salt, vinpocetine citrate, by neat co-grinding a

Integrity of crystalline lysozyme exceeds that of a spray

HSDSC revealed that crystallisation and spray drying did not affect the denaturation temperature of lysozyme in solution when compared with unprocessed material. However, in the solid state, FT-Raman spectra showed perturbation of the conformational structure of spray-dried sample, whereas crystal conformation remained intact.

Facile Spray-Drying Assely of Uniform …

2020-8-9 · Microencapsulates with defined core–shell structures are of interest for appliions, such as controlled release and encapsulation, because of the feasibility of fine-tuning individual functionalities of different parts. Here, we report a new approach for efficient and scalable production of such particles. Eudragit RS (a co-polymer of ethyl acrylate, methyl methacrylate, …

Fractal Structure of Microcrystalline Cellulose Obtained

2019-10-28 · Rod-shaped crystalline nanoparticles (CNP) of cotton cellulose with radius r = 3 nm have a compact packing with high true density (specific gravity) d=1.585g/cm3 and negligible porosity P o =0.03 cm3 g. During spray-drying a lateral aggregation of rod-shaped CNP occurs. Moreover, with the development of aggregation process of

Characterization of crystalline and spray-dried amorphous

Highlights. Spray-dried α-CD powder was in amorphous structure with T g ~ 83.4 °C. Water adsorption ability of spray-dried α-CD was higher than that of crystalline one. Water adsorption data of spray-dried α-CD were fitted well with GAB and BET models. Spray-dried α-CD powder crystallized as kept at above 65.25% RH condition for 3 weeks.

Crystallization of Amorphous Components in Spray-Dried

The major physical and structural deteriorative reactions that occur during processing and storage of foods are collapse of structure during freeze-and vacuum-drying [18,93], stickiness of food

Amorphous Solids - ICDD

2018-11-9 · Crystalline vs. amorphous structures • Crystalline: Local structure is repeated in space • Amorphous: Local structure might be “crystal like”, but is not repeated in space. Zallen, The Physics of Amorphous Solids, 1998

Control of crystalline particle properties by spray drying

Control of crystalline particle properties by spray drying

Dry Powder Precursors of Cubic Liquid Crystalline

Most of the current work is limited to liquid phase processes involving high shear dispersion of bulk cubic liquid crystalline material into sub-micron particles, limiting appliion flexibility. In this work, two types of dry powder cubosome precursors are produced by spray-drying: (1) starch-encapsulated monoolein is produced by spray-drying

Natural crystalline colorant and process for production

2018-11-6 · CROSS REFERENCE TO RELATED APPLIIONS. The present appliion claims priority to and is a divisional of U.S. appliion Ser. No. 15/449,828 entitled “NATURAL CRYSTALLINE COLORANT AND PROCESS FOR PRODUCTION” filed on Mar. 3, 2017, now U.S. Pat. No. 10,214,630, issued on Feb. 26, 2019,which claims priority to and is a …

Characterization of crystalline and spray-dried amorphous …

2015-11-1 · The FTIR spectra of amorphous and crystalline α-CDs (Supplementary materials, Fig. S.2) indies that both are characterized by (1) a broad band at 3000–3600 cm − 1 due to the symmetric and antisymmetric O–H stretching mode, and (2) a strong and complex band at 900–1180 cm − 1 arising from the stretching of C–O bonds.

Dry powder precursors of cubic liquid crystalline

2017-2-5 · liquid to be spray-dried into the top of the spray-dryer body. Air at a pressure of 300kPa is pumped through a 0.25-cm annular air orifice. Drying occurs via contact of the feed liquid with heated, drying air at 200 C that flows down past the nozzle. The short residence time of the spray-drier should prevent any oxidation of the

Characterization of crystalline and spray-dried amorphous

Request PDF | Characterization of crystalline and spray-dried amorphous α-cyclodextrin powders | Alpha-cyclodextrin (α-CD) powder has been used to adsorb organic compounds for various

Characterization of crystalline and spray-dried amorphous …

Highlights. Spray-dried α-CD powder was in amorphous structure with T g ~ 83.4 °C. Water adsorption ability of spray-dried α-CD was higher than that of crystalline one. Water adsorption data of spray-dried α-CD were fitted well with GAB and BET models. Spray-dried α-CD powder crystallized as kept at above 65.25% RH condition for 3 weeks.

Rapidly expanding starches with altered crystalline structure

Preparation of a Labile Birefringent Starch by Spray Drying. One Step Process. Spray drying was performed on a Niro Spray Dryer with a two fluid nozzle. The starch as prepared in Example 1 was slurried at 20-30% (w/w) solids in water and was introduced directly into the nozzle with the feed pressure of 20.6-24.0 MPa.

Stages or Process of Crystallization | AlaquaInc

Alaqua 7004 Boulevard East, Suite 28A,Guttenberg, NJ USA 07093 +(00-1) 551 482 7568 [email protected]

Impact of Crystalline and Amorphous Matrices on …

2021-5-7 · During the spray drying process, minor changes of T‐Out were observed. Hence, T‐Out was reported as mean with a deviation of ± 1.5 °C. 2.6 Z‐Average and PDI Measurements. To compare the effects of pumping and spray drying on polyplex content, 70 µL of freshly prepared polyplex suspension was compared to polyplexes after further processing.

The production of crystalline powders by spray drying to

The drying mechanism was then investigated through the co-spray drying of the API with LαH2O using the same spray dryer inlet temperatures and solvent compositions. PAR and LαH2O were co-SD at various Tin and Sc to investigate the effect of these parameters on the co-processing of the two components.